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KMID : 0378019750180030295
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New Medical Journal
1975 Volume.18 No. 3 p.295 ~ p.300
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Studies on the Effects of Sulfisoxazole on Developing Rat Fetuses
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李洸鎬/Lee, Kwang Ho
全京鎬/Chun, Kyung Ho
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Abstract
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Pregnant Sprague-Dawley rats were given consecutive daily oral doses of 500 and 1, 000 mg/kg from. the 9th to 14th day of gestation, and their effects were examined.
1. No significant decrease of fetal mortality was observed in all groups treated with sulfisoxazole ;fit 500 and 1, 000 mg/kg in rats.
2.. There was no decrease of fetal body weight gain at 500 mg/kg in rats, ,but in L 000 mg/kg groups there was slight inhibition in fetal body weight gains.
3. Slight decrease ´of fetal brain weight occurred in 1, 000 mg/.kg groups.
4. Only two kinds of anomalies, that is cleft palate, and micrognadia were observed in the 500 gm/kg and the 1, 000 mg/kg groups.
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